1-a list of references appears at the end of the descriptive text. Such compounds also are useful for immunodiagnostic purposes with respect to such individuals.Ĭocaine is an ecgonine ester compound of the formula: #STR1# (ref. Both these catalytic antibodies and the immunogens used to induce them are potentially useful for the treatment of individuals at risk for the abuse of cocaine. The resulting immunogens elicit the formation, in experimental animals, of antibodies capable of hydrolysis of cocaine. By these methods, the phosphonates are produced rapidly in satisfactory yields. This invention relates to the preparation, by chemical synthesis, of methyl ecgonine phosphonates as analogues of transition states for the hydrolysis of the benzoyl ester bond in cocaine, and their linking to carrier proteins. Government Printing Office, Washington DC 1991, 284-299. Kuhar, Eds.), NIDA Research Monograph #112, Superintendent of Documents, U.S. Lewin, in Emerging Technologies and New Directions in Drug Abuse Research (R.S. Potential haptens for the generation of catalytic antibodies`.Īldrich Catalog Handbook of Fine Chemicals p. et al `Phenylphosphonate monoester analogs of cocaine. Skokie 60077, II., USA (US) Chandrakumar N.S. et al `Antibody-catalyzed degradation of cocaine` Bioorg.
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